USANA InCelligence Technology

Unlock the Code for Personalized Optimal Health

Boundless possibilities for a healthy, happy life are coded within trillions of your cells. Unlock your cells’ ability to function optimally with USANA’s patent-pending InCelligence cell-signaling technology.

USANA’s powerful, highly targeted InCelligence blends go beyond simply nourishing cells. They trigger powerful protection mechanisms, such as the production of natural antioxidants, while also supporting our body’s natural cellular renewal processes. These combined benefits optimize cellular resilience, making your cells more adaptable and empowering your body to meet your unique health needs.

How USANA InCelligence Technology Works
Optimizing Cellular Function for Vibrant Health, Every Day

Your cells are smart. They know how to keep you healthy. They keep your body functioning normally by constantly communicating with each other using cell-signaling pathways.

USANA’s InCelligence Technology joins your cells’ conversation to unlock your cells’ ability to perform optimally.*

Like a key that fits in a lock, highly targeted nutrients fit into specific cell sites. This activates powerful cell-signaling pathways, which instruct cells to initiate a network of natural protection and renewal processes.*

Age or other lifestyle factors may slow down your body’s natural processes that keep you healthy. InCelligence proactively optimizes these processes. It’s like strength training for your cells.*

By building cellular resilience and supporting longevity of healthy cellular function, your body can thrive, even when facing challenges such as stress, less-than-ideal diets, or environmental toxins.*

InCelligence requires a solid foundation of vitamins, minerals, and other nutrients that nourish cells for maximum effectiveness. Our proprietary InCelligence products build upon this foundation, providing a number of different health-optimizing benefits. For example:

  • More powerful cellular protection against damaging oxidative stress by delivering dietary antioxidants and supporting production of endogenous antioxidants, such as glutathione and superoxide dismutase*
  • Renewed efficiency of cellular energy (ATP) production by purifying damaged mitochondria from cell through mitophagy*
  • Enhanced immunity through priming immune cells to respond to challenges effectively*
  • Balanced detoxification reactions to aid the body’s natural ability to remove toxins*

The Science of InCelligence
A New Era of Nutritional Science

Since the introduction of the USANA® EssentialsTM in 1992, USANA has set the standard for excellence in science-based nutrition and wellness products. InCelligence is the next revolution in creating optimal health through products that help your body adapt to your unique needs.*

Led by the visionary Dr. Myron Wentz, our in-house research and development team has integrated advances in the sciences of molecular biology and cell signalling with USANA’s expert knowledge of cellular nutrition to develop InCelligence Technology.

Research Partners
In addition to ongoing in-house studies, USANA continues to partner with respected research institutions to discover new frontiers of this exciting new science.

Ben A. Bahr, Ph.D., University of North Carolina – Pembroke
Sanoviv Medical Institute


Patents (pending or provisional)

  • Compositions for Upregulating Endogenous Antioxidant Systems
  • Methods and Compositions for Reducing Damage Associated with Oxidative Phosphorylation
  • Methods and Compositions for Supporting Endogenous Systems Related to Life Span

Dr. Myron Wentz’ experience using proper nutrition to optimize cellular health has influenced USANA —the company he founded in 1992— for more than two decades. His pioneering approach to antioxidants and cellular nutrition has been the catalyst for numerous innovations in nutritional supplements and personal care products.

The foundational understanding of nutrition’s role in cellular health remains, but an evolution of this understanding has taken place at USANA. Under the guidance of Dr. Wentz, scientists and researchers continued to study cellular processes and the role nutrients, bioflavonoids, and phytochemicals play in supporting good cellular health, specifically through optimal cell-to-cell communication.

This work has led to breakthroughs in USANA’s ability to utilize cell signaling and targeted nutrients to activate positive cellular responses that promote protection, renewal, and adaptation. The company’s cell-signaling knowledge has crystalized into a new product-formulation platform based on innate cellular intelligence— USANA InCelligence Technology™.

What is molecular or cell signaling?

Our body contains within it an incredibly elaborate and complex communication network that is reliant on a variety of molecules that act as informational messengers. Proteins, enzymes, hormones, cell receptors, binding sites, genes, and their transcription factors are all part of this system. They are responsible for the transmission of information that initiates and controls some of the most basic and yet life-essential functions in the human body. The activation of our immune system, the transfer of electrical impulses from one neuron to another throughout our nervous system and brain, the maintenance of growth, metabolism and repair, as well as the influence of gene expression are all accomplished through
the various chemicals and molecular messengers produced in our body. These communications can occur within the cell itself, from cell to cell
,from cell to tissue, or from tissue to organ, through a countless array of messenger chemicals, pathways, cross talk and conversational channels.

Scientists and researchers have now discovered that our food can also act as informational messengers; messengers that deliver vital and dynamic information that can have, depending on the quality and type of food, either a positive or negative consequence. Plant-based phyto
nutrients especially, can act as powerful signaling molecules which interact with our intrinsic cell-signaling pathways, initiating the activation of and influencing a variety of systems and bodily functions that include the immune system, healthy inflammatory response associated with exercise, and interior antioxidant defenses. It can also positively impact cellular performance through a process called mitophagy.

Genes, for instance, which are made up of DNA, are instructions for the creation of proteins. These proteins are responsible for the function, regulation and maintenance of an infinite number of essential and vital body processes. As mentioned above, our food can influence the expression of genes that are favorable to our health.

Food as Information: The History and Importance of Phytochemical Diversity

A discussion of the scientific inspiration for InCelligence cell-signaling technology must begin with an understanding of the way human cells interact with compounds that enter our bodies—specifically, food.

In a lifetime, humans consume 60–100 tons of food -about one ton per year (USDA). Every molecule of food is a messenger capable of carrying information across the gut barrier and into our cells, where it can impact our DNA. So, if a person’s DNA were itself a culinary dish, it would be an egg poached in a broth of his or her collective dietary choices. That illustrates the tremendous impact diet has on our DNA, our cells, and, as a result, our overall health.

And this is not a modern phenomenon. Over the last seven million years, Homo sapiens have co-evolved with their environment. A constant flow of chemical information —via molecular messaging— has shaped the relationship between humans and plants. This process is driven by the ability of secondary plant metabolites to influence their consumers on a physical level (attraction or repulsion), as well as a molecular level. One of the myriad examples is the ability of many flavonoids to influence gene transcription and utilize mammalian steroid receptors to modulate the endocrine system.

The impact of phytochemicals was amplified by the sheer diversity of plants consumed by past generations. For the vast majority of human evolution, our species regularly consumed 88 to 220 different plants as part of its diet, exposing cells to upwards of 200,000 phytochemicals. Even hunter-gatherer societies with greater access to meat were consuming roots, leaves and fruits, as well as leaner, omega-3 rich meat containing a variety of secondary plant metabolites.

The availability of such nutrient and phytonutrient diversity generation after generation limited humans’ ability to synthesize important molecules, like polyphenols. But we maintained processes that respond to plant-based messenger molecules, which suggest the response mechanisms hold significant evolutionary importance. The retention of this trait may be tied to a molecular early warning system for environmental change set off by phytochemicals that trigger an adaptive response in humans.

It’s no surprise a growing body of research suggests phytonutrients are favorable and necessary to human health. Multiple studies(Liu, 2003;
McCarty, 2004; Norris et al.,2003) showed a diet rich in phytochemicals—as part of a healthy lifestyle—is associated with efficient longevity. And low fat diets rich in fruits and vegetables (foods that are low in fat and may contain dietary fiber, vitamin A, and vitamin C) may reduce the risk of some types of cancer, a disease associated with many factors. Broccoli is high in vitamins A and C, and it is a good source of dietary fiber.

A key point is that the body’s response to these phytonutrients, provokes an innate cellular action that results in positive biological activity at the molecular level. We consider this a form of intelligence: Human cells demonstrate an innate cellular intelligence, or InCelligence, to act on the information from phyto-nutrients, found in USANA products.

Food-based cell-signaling molecules like phytonutrients have the ability to interact and converse with our internal communication network. And with the information they carry as messengers of health, plant-based phytonutrients have arguably become as indispensable to human health as vitamins and minerals.

On the other hand, poor food choices in addition to unhealthy chemicals and toxins can have the opposite effect, affecting genes in a deleterious way, influencing cell-signaling pathways that will set off a chain of events that can lead to poor health.

What is meant by pleiotropic?

When scientists and researchers turn to the topic of mechanism of action, they are referring to the way a molecule such as a drug or bio molecule affects a cell-signaling pathway and subsequently how it exerts its effect on a particular function or health condition. In drug development,
the goal is to have a strong effect on a particular biochemical pathway, a specificity to a particular molecular target, and little effect in the way of adverse events. This goal of potency, selectivity and acceptable toxicity is considered the holy grail of drug discovery. This selectivity does make pharmaceuticals strong but at a cost of a very high rate of adverse effects.

In understanding the mechanisms of action of biomolecules such as phytonutrients, it is important to note that these compounds rarely behave in the same way that synthetic molecules do in regard to potency, selectivity and toxicity. As plant-based compounds generally have numerous health benefits, unlike drugs, they influence a wide array of cell-signaling pathways. This concept of one molecule possessing numerous properties while exerting its influence over a wide range of signaling pathways, resulting in multiple effects, is called pleiotropism.

Greentea polyphenol EGCGpossesses quite an impressive array of health benefits. These many health benefits result fromEGCG’s pleiotropic activity, that is, numerous cell-signaling pathways are positively influenced. This multi-pathway approach makes for a dramatically
less invasive and less harmful approach, thus significantly reducing any potential prospect of adverse reaction.

USANA’s InCelligence Technology™

The concept of pleiotropism and the ability of plant-based phytonutrients to beneficially influence, engage and participate in cellular and molecular communication pathways is the primary advantage of using these compounds in the service of human health. By studying and thoroughly understanding these principles including mechanisms of action, USANA can accurately identify which plant compounds more significantly influence a certain set of cell-signaling pathways and thereby design products that can focus on a particular condition, system or function that is broad, providing multiple health advantages.

In summary, phytonutrients can interact and communicate with cell-signaling pathways that influence additional key pathways such as the inflammatory and immune response related to exercise and muscle exertion, neurological activity,and healthy insulin and glucose levels. These biomolecules can help modulate and improve our internal antioxidant defense system and cellular performance and subsequently the cell’s ability to generate energy.

InCelligence Technology by USANA is a revolution from the old paradigm of nutritional supplements. While the old approach is to provide support (such as substrates or co-factors) for functional proteins (such as enzymes, receptors, and transporters), InCelligence directly
engages these targets. Traditional multivitamin supplements supply the building materials, while the InCelligence paradigm puts the builders into action.

Through this approach, USANA has developed its new InCelligence Technology, a technology that understands the intimate partnership between beneficial plant-based compounds and nutrients and their dynamic interplay with our cellular and molecular communication system. We think of it as pleiotropic molecular nutrition. The outcome for the consumer of USANA products is added resilience and adaptation to the stressors that a consumer faces in their day-to-day life.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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